# Gene_Name Validated by OTP Gene Aliases pSites Up/Down/None in EPHB2 cells pSites Up/Down/None in EphrinB1 cells 1 AAAS Yes ADRACALIN, ALADIN 2 ABL1 Yes ABL, c-ABL y251, y412 y412 3 AHNAK Yes AHNAKRS, MGC5395 y121, y715, y836, y964, y1469 4 AK7 Yes ---- 5 AKAP13 Yes BRX, HT31, LBC 6 AMOTL1 Yes ---- y191 7 ANKS1A Yes ANKS1 y834 8 APAF1 Yes ---- 9 APC Yes BTPS2, DP2, DP3, GS y2645 y2645 10 ARHGAP18 Yes ---- 11 ARHGEF10 Yes ---- 12 ARHGEF4 Yes ASEF, ASEF1, GEF4, STM6 13 ASH1L Yes ---- 14 AURKC Yes AIE2, AIK3, STK13 15 AXIN1 Yes ---- 16 BCAR1 Yes CAS, CAS1, CASS1, CRKAS, P130Cas y128, y234, y267, y387, y410 y128, y234, y249 17 BCAR3 Yes NSP2, SH2D3B 18 BCAS3 Yes GAOB1, MAAB 19 BICC1 Yes ---- 20 BRPF1 Yes BR140 21 BRPF3 Yes KIAA1286 22 BUB3 Yes BUB3L 23 CALM3 Yes PHKD, PHKD3 24 CAMK1 Yes ---- 25 CAMKK2 Yes CAMKKB, KIAA0787 26 CBL Yes CBL2, RNF55 27 CBLB Yes RNF56 28 CBLC Yes CBL3, RNF57 29 CCDC50 Yes C3orf6 y144, y145, y455 30 CDC42BPG Yes DMPK2, HSMDPKIN 31 CDK5RAP1 Yes C20orf34 32 CFL1 Yes CFL y84, y88, y139 y84, y88, y139 33 CHN1 Yes ARHGAP2, CHN 34 CHN2 Yes ARHGAP3, BCH 35 CNKSR1 Yes CNK1 36 COPB2 Yes ---- 37 CRK Yes CRKII y221 y221 38 CRKL Yes ---- y132 y198, y207 39 CTEN Yes TNS4 40 CTNNA1 Yes ---- y177 41 DGKD Yes KIAA0145 42 DNAI1 Yes ---- 43 DNM1 Yes DNM 44 DOCK1 Yes ced5, DOCK180 45 DOCK5 Yes ---- 46 DSG2 Yes ARVC10, HDGC y605, y801, y883 47 DUSP5 Yes HVH3 48 DYRK2 Yes ---- 49 EFNB1 Yes EFNB1 y313, y317 y313, y317, y343 50 ELMO1 Yes KIAA0281 51 ELMO3 Yes ---- 52 EML4 Yes ---- y226 53 EPB41L1 Yes 4.1N 54 EPHA8 Yes EEK, HEK3 55 EPHB2 Yes DRT, EPHT3, EPTH3, ERK, HEK5, NUK, TYRO5 y577, y584, y596, y602, y780 y584, y596, y602, y780 56 ERBB4 Yes HER4 57 EYA3 Yes ---- 58 FAK Yes PTK2 y576, y577 y576, y577 59 FBXW11 Yes BTRCP2, FBW1B, FBXW1B, KIAA0696 60 FERMT3 Yes KIND3, MIG2B, URP2 61 FGD1 Yes FGDY, ZFYVE3 62 FRS3 Yes FRS2B, FRS2beta, FRS3, MGC17167, SNT-2, SNT2 63 GAB3 Yes ---- 64 GALK1 Yes GALK, GK1 65 GDI1 Yes GDIL, OPHN2, RABGDIA, XAP4 66 GDI2 Yes RABGDIB y203 y203 67 GPSM1 Yes AGS3 68 GRAP Yes ---- 69 GRB10 Yes GRBIR, KIAA0207 70 GRB2 Yes ASH 71 GRB7 Yes ---- 72 GRIP1 Yes GRIP 73 HECW2 Yes KIAA1301, NEDL2 74 HIRA Yes DGCR1, HIR, TUPLE1 75 HRAS Yes HRAS 76 HUWE1 Yes KIAA0312, KIAA1578, UREB1 77 ING5 Yes p28ING5 78 INPPL1 Yes SHIP2 y886, y986, y987, y1135 y886, y1135 79 INTU Yes INT, PDZD6, PDZK6 80 IQCK Yes MGC35048 81 IQGAP2 Yes ---- 82 IRS2 Yes ---- y542, y598, y632, y653, y675, y742, y823 y542, y598, y632, y653, y675, y742, y823 83 ITGB1 Yes FNRB, MDF2, MSK12 y783, y795 y783 84 ITSN2 Yes KIAA1256, SH3D1B, SWAP y553, y968 y553, y968 85 JADE1 Yes PHF17 86 JAK2 Yes JTK10 87 JMJD2A Yes JHDM3A, JMJD2, KIAA0677 88 JUP Yes CTNNG, DP3 y20 89 KIRREL Yes KIRREL1, NEPH1 y641, y669, y737, y740 y641, y737 90 LNK Yes SH2B3 91 LRP6 Yes ADCAD2 y1562 92 LRRIQ2 Yes CEP97 93 MAP2K5 Yes MEK5, MKK5, PRKMK5 94 MAP2K6 Yes MEK6, MKK6, PRKMK6 95 MAP3K2 Yes MAPKKK2, MEKK2 96 MAP3K5 Yes ASK1, MAPKKK5, MEKK5 97 MAPK8IP1 Yes IB1, JIP1, PRKM8IP 98 MAPKAPK2 Yes ---- 99 MARK4 Yes KIAA1860, MARKL1 100 MEP50 Yes WDR77 101 MLL2 Yes ALR, KMT2B 102 MORG1 Yes MGC4238 103 MPP3 Yes DLG3 y705 y705 104 MPP4 Yes ALS2CR5, DLG6 105 MPP7 Yes FLJ32798 y354, y417, y440, y444 106 NCK2 Yes GRB4, NCKb 107 NEK9 Yes KIAA1995, NEK8, NERCC 108 NRAS Yes ALPS4, N-ras, NRAS1 109 NUMBL Yes CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23 110 OSBP2 Yes KIAA1664, ORP4, OSBPL4 111 PAG1 Yes CBP, PAG y163, y181, y227, y317, y341, y359 y181, y227, y317, y341, y359, y417 112 PAK1 Yes PAKa 113 PARD3 Yes PAR3, PAR3A y377, y388, y489, y719, y933, y1080, y1127, y1244, y1310, y1321 y388, y489, y719, y1080, y1127, y1244, y1310 114 PARD6A Yes PAR6A 115 PARD6B Yes PAR6B y101 116 PDGFRA Yes CD140A, MGC74795, PDGFR2, Rhe-PDGFRA 117 PDGFRB Yes CD140B, JTK12, PDGFR, PDGFR1 118 PDLIM4 Yes RIL 119 PHF11 Yes BCAP 120 PHKA2 Yes PHKLA, PYK 121 PIK3R4 Yes p150, VPS15 122 PKN2 Yes PRK2, PRKCL2 y635 123 PKP4 Yes ---- y157, y372, y415, y420, y465, y478, y494, y1117, y1170 y157, y369, y372, y415, y421, y478, y494, y1117, y1170 124 PLCB2 Yes ---- 125 PLCB4 Yes PI-PLC 126 PLCG1 Yes PLC1 y893 y893, y905 127 PLCG2 Yes ---- y1217 128 PPP2R2A Yes ---- 129 PREB Yes SEC12 130 PREX1 Yes KIAA1415 131 PRKCSH Yes G19P1 132 PTEN Yes MMAC1, TEP1 133 PTPN11 Yes CFC, NS1, SHP2 y62, y542, y580 y62, y542, y580 134 PTPN6 Yes HCP, PTP1C, SHP1 135 PTPN9 Yes MEG2, PTPMEG2 136 PTPRK Yes PTPK 137 PTPRR Yes ECPTP, PTPRQ 138 PXN Yes ---- y88, y118 y88, y118 139 RABGAP1 Yes GAPCENA, TBC1D11 140 RAC1 Yes MIG5 141 RADIL Yes FLJ10324, KIAA1849 142 RALGDS Yes KIAA1308, RalGEF, RGF 143 RAPGEF1 Yes C3G, GRF2 144 RAPH1 Yes ALS2CR18, ALS2CR9, KIAA1681, LPD, PREL2, RMO1 145 RASA1 Yes p120GAP, p120RasGAP 146 RASAL2 Yes NGAP 147 RASGRP1 Yes RASGRP 148 RASGRP2 Yes CDC25L, MCG7 149 RHOA Yes ARH12, ARHA, RHO12 150 RIN1 Yes ---- y36 y36 151 RIOK1 Yes ---- 152 RNGTT Yes CAP1A 153 ROCK1 Yes P160ROCK, ROCK 154 RRAS Yes ---- 155 SCAP2 Yes PRAP, RA70, SAPS, SCAP2, SKAP55R 156 SCML2 Yes ---- 157 SCRIB Yes CRIB1, KIAA0147, LAP4, SCRB1, VARTUL y834 y834 158 SDCBP2 Yes SITAC18 159 SHB Yes ---- y182, y200, y332, y354, y422 y200, y332, y354, y422 160 SHC1 Yes SHCA y428 y428 161 SHC3 Yes NSHC, SHCC 162 SHC4 Yes RaLP, SHCD 163 SLC9A3R2 Yes NHERF2, SIP1 164 SNTB2 Yes D16S2531E, SNT2B2, SNTL 165 SNX26 Yes TCGAP 166 SOCS7 Yes NAP4, SOCS6 167 SOS1 Yes GF1, GGF1, GINGF, HGF, NS4 168 SPTA1 Yes EL2, SPTA 169 SSH1 Yes KIAA1298, SSH1L 170 STAP1 Yes BRDG1 171 STARD13 Yes DLC2, GT650 172 STAT3 Yes APRF y704, y708 y704, y708 173 STAT5A Yes MGF, STAT5 174 STK24 Yes MST3, STK3 175 STK38L Yes KIAA0965, NDR2 176 STRN4 Yes ZIN 177 SYT4 Yes KIAA1342 178 TBC1D2 Yes PARIS1, TBC1D2A 179 TBL1X Yes EBI, SMAP55, TBL1 180 TCERG1 Yes CA150, TAF2S 181 TGFBR2 Yes TGFR-2 182 TJP2 Yes X104, ZO-2 y261, y426, y911, y1007, y1118 y426, y1007, y1118 183 TNFRSF10A Yes APO2, DR4, TRAILR1 184 TNK2 Yes ACK1 y596, y937 y347, y596 185 TNS3 Yes TEM6, TENS1, TPP 186 TRIM28 Yes KAP1, RNF96, TIF1B 187 TTBK1 Yes BDTK, KIAA1855 188 TTN Yes CONNECTIN 189 TYRO3 Yes BYK, DTK, RSE, SKY y685, y828 y828 190 ULK2 Yes KIAA0623 191 USH1G Yes SANS 192 WASL Yes N-WASP y256 y256 193 WDR34 Yes MGC20486 194 WDR40B Yes ---- 195 WIF1 Yes WIF-1 196 WIPI1 Yes WIPI49 197 WNK1 Yes KDP, KIAA0344, PRKWNK1 y2276 198 YAP1 Yes YAP65 199 YES Yes c-YES, YES1 200 ZYX Yes ESP-2, HED-2